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KMID : 1035620160040010074
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Allergy Asthma & Respiratory Disease
2016 Volume.4 No. 1 p.74 ~ p.78
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Rapid-onset of severe tigecycline-induced coagulopathy in drug reaction with eosinophilia and systemic symptom syndrome
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Jeong Yeong-Jin
Kang Byung-Ju
Lee Ji-Wan
Park Jin-Oh
Kim Tae-Bum
Cho Yoo-Sook
Moon Hee-Bom
Kwon Hyouk-Soo
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Abstract
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Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome?also known as drug-induced hypersensitivity syndrome?is an uncommon disease entity that manifests as fever, skin rash, blood cell abnormalities, lymphadenopathy, and often coagulopathy. Tigecycline is an antibiotic that is selectively used to treat complicated intra-abdominal and soft-tissue infections. Recently, a few cases of tigecycline-induced coagulopathy have been reported. Herein, we report a case of tigecycline-induced coagulopathy in a patient with DRESS syndrome. Both prothrombin time and activated partial thromboplastin time were abruptly exceeded beyond 180 seconds on day 6 of tigecycline treatment and normalized after discontinuation of tigecycline.
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KEYWORD
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DRESS syndrome, Tigecycline, Coagulopathy
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